National Research Council of Canada. Human Health Therapeutics
International Federation of Placental Associations Conference (IFPA EPG 2014), Sept 9-12, 2014, Paris, France
Salmonella enterica species are intracellular pathogens causative agents of gastroenteritis and typhoid fever in humans worldwide. Pregnancy poses an increased risk of severe Salmonellosis in many mammalian species contributing to miscarriage and maternal illness. Previous studies have indicated that Salmonella enterica Typhimurium (S. Tm) rapidly replicates within murine placenta leading to placental inflammation and death. Furthermore, IL-10 production by human choriocarcinoma trophoblast cells was shown to delay phagosomal maturation facilitating intracellular pathogen replication. The objective of this study was to evaluate the potential vulnerability of human primary trophoblast cells (TBCs) to S. Tm infection and elucidate the mechanism of cell death and inflammation.