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Vaccines against Francisella tularensis

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1196/annals.1409.012
AuthorSearch for: 1; Search for:
Affiliation
  1. National Research Council of Canada. NRC Institute for Biological Sciences
FormatText, Article
Subjectadverse effects; bacterial vaccines; Francisella tularensis; genetics; immunity, cellular; immunity, natural; immunology; molecular; mutation; pathogenicity; physiology; potential; prevention & control; strain; tularemia; united states food and drug administration; vaccines; virulence; virulence factors
Abstract
Francisella tularensis is one of the most pathogenic pathogens known, especially when disseminated as a small particle aerosol. Because of this, it was developed into a biological warfare agent by several states during the 20th century. Nowadays, concerns remain about the potential of this pathogen to cause widespread disease, tularemia, in the hands of terrorists. This has resurrected interest in methods to combat it. This article reviews the current status of vaccine development efforts against tularemia. To date most of our understanding of tularemia vaccine efficacy has been derived from the clinical and experimental use of a pragmatically attenuated live vaccine strain of F. tularensis subspecies holarctica. However, this vaccine which has been in existence for more than 50 years is still beset by regulatory issues that continue to hamper its licensure. These issues and possible solutions are highlighted, along with more modern molecular approaches to vaccine development against this highly virulent pathogen.
Publication date
PublisherWiley
In
  • Annals of the New York Academy of Sciences 1105, no. 1: 325–350.
LanguageEnglish
Peer reviewedYes
NRC numberCONLAN2007
WAYNE2007
NPARC number9368974
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Record identifier0171d21c-5aba-49ef-a00b-64ae55af6698
Record created2009-07-10
Record modified2020-05-10
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