| Download | - View final version: Purifying selection on deleterious variants affected by the combination of subgenomes and gene expression in bread wheat (PDF, 4.9 MiB)
|
|---|
| DOI | Resolve DOI: https://doi.org/10.1016/j.celrep.2025.116785 |
|---|
| Author | Search for: Halstead-Nussloch, Gwyneth; Search for: Okada, Moeko; Search for: Haberer, Georg; Search for: Lux, Thomas; Search for: Islam, A.S.M. Faridul; Search for: Hatakeyama, Masaomi; Search for: Briskine, Roman; Search for: White, Benjamen; Search for: Hall, Anthony; Search for: Pozniak, Curtis; Search for: Walkowiak, Sean; Search for: Klymiuk, Valentyna; Search for: Byrns, Brook; Search for: Nilsen, Kirby; Search for: Ens, Jennifer; Search for: Wiebe, Krystalee; Search for: Diaye, Amidou N’; Search for: Hucl, Pierre J.; Search for: Pozniak, Curtis; Search for: Fu, Bin Xiao; Search for: Gao, Liangliang; Search for: Delorean, Emily; Search for: Koo, Dal-Hoe; Search for: Fritz, Allen K.; Search for: Poland, Jesse A.; Search for: Monat, Cecile; Search for: Himmelbach, Axel; Search for: Fiebig, Anne; Search for: Padmarasu, Sudharsan; Search for: Scholz, Uwe; Search for: Mascher, Martin; Search for: Stein, Nils; Search for: Haberer, Georg; Search for: Gundlach, Heidrun; Search for: Mayer, Klaus F.X.; Search for: Spannagl, Manuel; Search for: Kassa, Mulualem T.; Search for: Fobert, Pierre; Search for: Kagale, Sateesh1ORCID identifier: https://orcid.org/0000-0002-7213-1590; Search for: Brinton, Jemima; Search for: Ramirez-Gonzalez, Ricardo H.; Search for: Bevan, Michael; Search for: McKenzie, Neil; Search for: Steuernagel, Burkhard; Search for: Uauy, Cristobal; Search for: Kolodziej, Markus C.; Search for: Krattinger, Simon G.; Search for: Keller, Beat; Search for: Wicker, Thomas; Search for: Thambugala, Dinushika; Search for: McCartney, Curt A.; Search for: Bandi, Venkat; Search for: Siri, Jorge Nunez; Search for: Gutwin, Carl; Search for: Aquino, Catharine; Search for: Hatakeyama, Masaomi; Search for: Copetti, Dario; Search for: Halstead-Nussloch, Gwyneth; Search for: Paape, Timothy; Search for: Shimizu-Inatsugi, Rie; Search for: Shimizu, Kentaro K.; Search for: Ban, Tomohiro; Search for: Kawaura, Kanako; Search for: Tameshige, Toshiaki; Search for: Tsuji, Hiroyuki; Search for: Venturini, Luca; Search for: Clark, Matthew; Search for: Fosker, Christine; Search for: Accinelli, Gonzalo Garcia; Search for: Heavens, Darren; Search for: Krasileva, Ksenia; Search for: Swarbreck, David; Search for: Wright, Jonathan; Search for: Hall, Anthony; Search for: Gardner, Keith A.; Search for: Fradgley, Nick; Search for: Percival-Alwyn, Lawrence; Search for: Cockram, James; Search for: Gutierrez-Gonzalez, Juan; Search for: Muehlbauer, Gary; Search for: Koh, Chu Shin; Search for: Sharpe, Andrew G.; Search for: Deek, Jasline; Search for: Costamagna, Alejandro C.; Search for: Kanamori, Hiroyuki; Search for: Kobayashi, Fuminori; Search for: Tanaka, Tsuyoshi; Search for: Wu, Jianzhong; Search for: Handa, Hirokazu; Search for: Kuo, Tony; Search for: Sese, Jun; Search for: Murata, Kazuki; Search for: Nabeka, Yusuke; Search for: Nasuda, Shuhei; Search for: Juliana, Philomin; Search for: Singh, Ravi; Search for: Budak, Hikmet; Search for: Small, Ian; Search for: Melonek, Joanna; Search for: Cloutier, Sylvie; Search for: Keeble-Gagnère, Gabriel; Search for: Tibbets, Josquin; Search for: Legg, Erik; Search for: Bharti, Arvind; Search for: Langridge, Peter; Search for: Distelfeld, Assaf; Search for: Spannagl, Manuel; Search for: Paape, Timothy; Search for: Shimizu, Kentaro K.ORCID identifier: https://orcid.org/0000-0002-6483-1781; Search for: BernardoClavijo; Search for: KenChalmers |
|---|
| Affiliation | - National Research Council Canada. Aquatic and Crop Resource Development
|
|---|
| Funder | Search for: Japan Society for the Promotion of Science; Search for: University of Zurich; Search for: Core Research for Evolutional Science and Technology; Search for: Swiss National Science Foundation; Search for: Genome Canada; Search for: Western Grains Research Foundation; Search for: Manitoba Crop Alliance; Search for: Japan Science and Technology Agency; Search for: Saskatchewan Wheat Development Commission; Search for: Genome Prairie; Search for: Saskatchewan Ministry of Agriculture |
|---|
| Format | Text, Article |
|---|
| Subject | wheat; genome; transcriptome; purifying selection; subgenome; allohexaploid; evolution |
|---|
| Abstract | The genome-wide pattern of purifying selection on deleterious variants has attracted broad interest in breeding and evolutionary biology. Little is known about purifying selection in polyploid species with potential functional redundancy of duplicated homoeologs. Here, we examine the pattern of polymorphisms and the combined effects of both subgenome and gene expression on estimates of purifying selection in the allohexaploid bread wheat. We utilize the de novo annotated assemblies and transcriptome data of the 10+ Wheat Genome Project. Purifying selection is detected after filtering chromosomes harboring segregating foreign introgression by modern breeding. Interestingly, strong purifying selection is observed in the category of genes that are highly expressed in root tissues and are in the D subgenome, which is thought to contribute to the range expansion after allopolyploidization. We suggest that the combination of expressed tissues and subgenomes will inform the target of future wheat breeding to mitigate the effect of deleterious variants. |
|---|
| Date published | 2026-02-24 |
|---|
| Publisher | Elsevier B.V. |
|---|
| Copyright statement | - © 2025 The Author(s). Published by Elsevier Inc.
|
|---|
| Licence | |
|---|
| In | |
|---|
| Language | English |
|---|
| Peer reviewed | Yes |
|---|
| Identifier | S2211124725015578 |
|---|
| Export citation | Export as RIS |
|---|
| Report a correction | Report a correction (opens in a new tab) |
|---|
| Record identifier | 01735de3-a30e-4de3-9b45-d1cfa61ee9ff |
|---|
| Record created | 2026-06-26 |
|---|
| Record modified | 2026-07-14 |
|---|
