Local mechanical and structural properties of healthy and diseased human ascending aorta tissue

From National Research Council Canada

DOI	Resolve DOI: https://doi.org/10.1016/j.carpath.2008.01.001
Author	Search for: Choudhury, Nusrat; Search for: Bouchot, Olivier; Search for: Rouleau, Leonie; Search for: Tremblay, Dominique; Search for: Cartier, Raymond; Search for: Butany, Jagdish; Search for: Mongrain, Rosaire; Search for: Leask, Richard L.
Format	Text, Article
Subject	Aorta; Bicuspid; Mechanics; Hemodynamics; Elastic modulus
Abstract	Objective: This study investigates the mechanics and histology of healthy and dilated human ascending aortas (AA). The regional variation in mechanical response and tissue structure were compared. Methods: Rings of human AA from healthy (n=5), dilated tricuspid aortic valve (TAV, n=5), and dilated bicuspid aortic valve (BAV, n=6) patients were mechanically tested. Each aortic ring was sectioned into quadrants—anterior, posterior, medial (inner curvature) and lateral (outer curvature). Low- and high-stress elastic moduli were calculated from the equibiaxial stress strain curve to determine the local mechanical properties. Histological analysis was used to quantify the percent composition of elastin, collagen, and smooth muscle cells. Results: BAV tissue was thinnest and contained the largest percent composition of collagen. Both TAV and BAV tissue had significantly less elastin than healthy tissue. At low strain in the circumferential direction, TAV tissue was on average the least stiff. The elastic modulus was dependent on quadrant and tissue type but not direction (isotropic). Generally, the lateral quadrant tissue was the stiffest and the medial quadrant the least stiff. There were no apparent local variations in the tissue histology. Conclusions: Local variations in tissue thickness and mechanical properties were evident in all samples analyzed and may be linked to the type of aortic valve present.
Publication date	2009-03-05
In	Cardiovascular Pathology 18, no. 2 (5 March 2009): 83–91.
Language	English
Peer reviewed	Yes
NRC publication	This is a non-NRC publication "Non-NRC publications" are publications authored by NRC employees prior to their employment by NRC.
NPARC number	21276811
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Record identifier	0178ccc0-4ff1-4a05-a047-72386624a46c
Record created	2015-10-22
Record modified	2020-04-16

Date modified:: 2025-11-18