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Nitric oxide inhibitory isopimarane-type diterpenes from Orthosiphon stamineus of Indonesia

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1021/np020455x
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FormatText, Article
Abstract
A methanolic extract of Orthosiphon stamineus yielded six new highly oxygenated isopimarane-type diterpenes, orthosiphols U-Z (1-6), and 15 previously reported diterpenes. The isolated diterpenes all showed significant dose-dependent inhibitory effects on the nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells. Orthosiphols A (7), B (8), D (9), and X (4) showed more potent inhibitory activities than a positive control, N(G)-monomethyl-l-arginine (l-NMMA), and 1 displayed the strongest activity with an IC(50) value of 6.4 microM.
Publication date
In
  • Journal of Natural Products 66, no. 2 (28 January 2003): 255–258.
LanguageEnglish
Peer reviewedYes
NRC publication
This is a non-NRC publication

"Non-NRC publications" are publications authored by NRC employees prior to their employment by NRC.

NPARC number21274453
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Record identifier01c2e7ad-5d8c-44be-807c-73462ac87c2f
Record created2015-03-13
Record modified2020-04-02
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