| DOI | Resolve DOI: https://doi.org/10.1109/LISSA.2011.5754179 |
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| Author | Search for: Wong, Peter; Search for: Choi, Michael A.; Search for: Gul-Uludag, Hilal; Search for: Ang, Woon T.; Search for: Xu, Peng; Search for: Xing, James; Search for: Chen, Jie1 |
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| Affiliation | - National Research Council of Canada. National Institute for Nanotechnology
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| Format | Text, Article |
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| Conference | 2011 IEEE/NIH Life Science Systems and Applications Workshop, LiSSA 2011, April 7-8, 2011, Bethesda, MD, USA |
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| Subject | Lipofectamine; Synergistic properties; Transfection reagents; Ultrasound-mediated gene delivery; Gene therapy; Gene transfer; Liposomes; Ultrasonics |
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| Abstract | In this paper, we explore the possibility of increasing the transfection rate of hard-to-transfect cells (such as KG-1 cells) using ultrasound-mediated gene delivery (USD). Single application ultrasound induced as well as the synergistic properties of ultrasound with commonly used transfection reagents and repeated sessions USD were investigated and evaluated using GFP plasmid. KG-1 cells were not transfected by combining a commonly used transfection reagent and USD. However, repeated ultrasound-mediated treatments were able to increase transfection rate to 15% with a viability of 97%, as compared to 2% with the transfection reagent, Lipofectamine, alone. © 2011 IEEE. |
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| Publication date | 2011 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 21271995 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 080008ea-cd95-4ba8-8fc9-aaa255be2200 |
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| Record created | 2014-05-16 |
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| Record modified | 2020-04-21 |
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