Novel ethyl-derivatization approach for the determination of fluoride by headspace gas chromatography/mass spectrometry

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Download	View accepted manuscript: Novel ethyl-derivatization approach for the determination of fluoride by headspace gas chromatography/mass spectrometry (PDF, 1.9 MiB)
DOI	Resolve DOI: https://doi.org/10.1021/ac302303r
Author	Search for: Pagliano, Enea¹; Search for: Meija, Juris¹ORCID identifier: https://orcid.org/0000-0002-3349-5535; Search for: Ding, Jianfu²; Search for: Sturgeon, Ralph E.¹; Search for: D'Ulivo, Alessandro; Search for: Mester, Zoltán¹ORCID identifier: https://orcid.org/0000-0002-2377-2615
Affiliation	National Research Council of Canada. Measurement Science and Standards National Research Council of Canada. Security and Disruptive Technologies
Format	Text, Article
Subject	adverse effect; batch reactions; certified reference materials; closed vessels; derivatizations; fluoride ion; gas chromatography/Mass spectrometry; headspace gas chromatography; headspaces; limit of detection; linear range; non-volatile; one-step reactions; standard addition; tap water; tetrachloroferrate; chromatography; iron compounds; organic solvents; seawater; spectrometry
Abstract	We report a novel derivatization chemistry for determination of fluoride based on the batch reaction of fluoride ions with triethyloxonium tetrachloroferrate(III) in a closed vessel to yield fluoroethane. Gaseous fluoroethane was readily separated from the matrix, sampled from the headspace, and determined by gas chromatography/mass spectrometry. The method was validated using rainwater certified reference material (IRMM CA408) and subsequently applied to the determination of fluoride in various matrixes, including tap water, seawater, and urine. An instrumental limit of detection of 3.2 μg/L with a linear range up to 50 mg/L was achieved. The proposed derivatization is a one-step reaction, requires no organic solvents, and is safe, as the derivatizing agent is nonvolatile. Determination of fluoride is affected by common fluoride-complexing agents, such as Al(III) and Fe(III). The effect of large amounts of these interferences was studied, and the adverse effect of these ions was eliminated by use of the method of standard additions.
Publication date	2012-12-10
In	Analytical Chemistry 85, no. 2: 877–881.
Language	English
Peer reviewed	Yes
NPARC number	21270353
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Record identifier	09525e2a-5f5b-486b-8ef4-838601e78703
Record created	2014-02-04
Record modified	2020-06-04

Date modified:: 2024-07-19