| DOI | Resolve DOI: https://doi.org/10.1007/s12551-012-0077-8 |
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| Author | Search for: Ko, Alex C.-T.1; Search for: Ridsdale, Andrew2; Search for: Mostaço-Guidolin, Leila B.; Search for: Major, Arkady; Search for: Stolow, Albert2; Search for: Sowa, Michael G.1 |
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| Affiliation | - National Research Council of Canada. NRC Institute for Biodiagnostics
- National Research Council of Canada. NRC Steacie Institute for Molecular Sciences
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| Format | Text, Article |
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| Subject | Atherosclerosis; Nonlinear optical microscopy; Second-harmonic generation; Two-photon excited fluorescence; Coherent anti-Stokes Raman; Artery |
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| Abstract | Pathological understanding of arterial diseases is mainly attributable to histological observations based on conventional tissue staining protocols. The emerging development of nonlinear optical microscopy (NLOM), particularly in second-harmonic generation, two-photon excited fluorescence and coherent Raman scattering, provides a new venue to visualize pathological changes in the extracellular matrix caused by atherosclerosis progression. These techniques in general require minimal tissue preparation and offer rapid three-dimensional imaging. The capability of label-free microscopic imaging enables disease impact to be studied directly on the bulk artery tissue, thus minimally perturbing the sample. In this review, we look at recent progress in applications related to arterial disease imaging using various forms of NLOM. |
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| Publication date | 2012-05-17 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 21186085 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 09f20a48-1e98-4b86-9450-44c3b4bb2841 |
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| Record created | 2013-01-09 |
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| Record modified | 2020-04-21 |
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