| Download | - View accepted manuscript: A multiple recording patch clamp chip with integrated subterranean microfluidic channels for cultured neuronal networks (PDF, 939 KiB)
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| Author | Search for: Py, Christophe1; Search for: Mealing, Geoff1; Search for: Denhoff, Mike1; Search for: Charrier, Anne; Search for: Monette, Robert1; Search for: Comas, Tanya1; Search for: Ahuja, Tarun1; Search for: Martinez, Dolores1; Search for: Krantis, Anthony; Search for: Wingar, Simon1 |
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| Affiliation | - National Research Council of Canada. NRC Institute for Microstructural Sciences
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| Format | Text, Article |
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| Conference | Twelfth International Conference on Miniaturized Systems for Chemistry and Life Sciences, 12-16 October 2008, San Diego, California, USA |
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| Abstract | We report on a new type of patch-clamp chip that can simultaneously monitor electrophysiological activity from several individual neurons grown in simple networks. As in automated patch-clamp chips used for isolated cells in suspension, cells are interrogated using a microhole integrated into a membrane. The novelty of our chip resides in its capacity to position, culture and guide neurons into organized networks over multiple interrogation sites, thereby permitting high resolution monitoring of pre and post synaptic activity in these networks. |
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| Publication date | 2008-10 |
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| In | |
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| Language | English |
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| NPARC number | 21262545 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 1136b426-c31e-47bb-b1db-848cc577953f |
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| Record created | 2013-03-13 |
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| Record modified | 2020-06-04 |
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