| Download | - View final version: Editorial: Recent advances in the development of vaccines against Acinetobacter baumannii (PDF, 401 KiB)
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| DOI | Resolve DOI: https://doi.org/10.3389/fimmu.2023.1187554 |
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| Author | Search for: Khalili, Saeed; Search for: Chen, Wangxue1; Search for: Jahangiri, Abolfazl |
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| Affiliation | - National Research Council of Canada. Human Health Therapeutics
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| Format | Text, Article |
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| Subject | vaccine; active immunization; antigen; protection; immunogen; Acinetobacter baumannii |
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| Abstract | Acinetobacter baumannii is a notorious Gram-negative healthcare-associated (nosocomial and community-acquired) bacterial pathogen that causes a high mortality rate (up to 70%). The rapid emergence of highly antibiotic-resistant strains is a further propellant to introduce the bacterium as a serious public health threat. Hence, the World Health Organisation (WHO) listed A. baumannii (carbapenem-resistant) as the first priority that needs new antibiotics. The recent coronavirus disease 2019 (COVID-19) pandemic further increased the outbreak of carbapenem-resistant A. baumannii infections. Many novel antibiotics were introduced into the market but few are effective against A. baumannii. Hence, further approaches such as immunization trials had been considered as alternative solutions against A. baumannii infections. Several antigens had been introduced for active and passive immunizations. An effective robust immunization should develop full protection against various types of infections and all pathogenic strains. Moreover, it should have no deleterious effect on microbiota as well as the human proteome. Despite rigorous basic and pre-clinical studies conducted on active and passive immunizations against this pathogen, no vaccine has been advanced to clinical trials. Recently, the combination of protective antigens, epitopes/peptides or presentation of protective epitopes by appropriate scaffold had been suggested as effective promising approaches against A. baumannii. |
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| Publication date | 2023-05-30 |
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| Publisher | Frontiers Media |
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| Licence | |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 1164adcf-eadf-49d1-aa04-8ca6709cbd55 |
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| Record created | 2024-06-03 |
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| Record modified | 2024-06-03 |
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