| DOI | Resolve DOI: https://doi.org/10.1016/S0891-5849(96)00276-6 |
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| Author | Search for: Moore, A.N.J.1; Search for: Ingold, K. U.1 |
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| Affiliation | - National Research Council of Canada
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| Format | Text, Article |
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| Subject | alpha tocopherol; alpha tocopherylquinone; free radical; anticoagulant therapy; drug blood level; drug effect; drug transformation; heart infarction; stroke; Administration, Oral; Aged; Biotransformation; Gas Chromatography-Mass Spectrometry; Intestinal Absorption; Male; Vitamin E |
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| Abstract | The conversion of α-tocopheryl quinone into α-tocopherol in humans has been demonstrated. A male subject was given an oral dose of 400 mg of α- 3,5-[(C2H3)2]-tocopheryl quinone with an evening meal. Analysis of plasma 15 h later by lipid extraction and subsequent GC-MS single ion monitoring revealed the presence of α-[5,7(C2H3)2]-tocopherol at a concentration of 0.4 μM, representing 0.8% of the total tocopherol in the plasma sample. This experiment clearly demonstrates that orally administered α tocopheryl quinone is converted in a low overall yield to α-tocopherol in humans. The conversion to α-tocopherol of that portion of the quinone dose which was actually absorbed into the blood stream may, however, have been fairly efficient. |
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| Publication date | 1997 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 21276524 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 12bc1697-913c-47d8-998b-62a1513a6c78 |
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| Record created | 2015-10-13 |
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| Record modified | 2020-03-20 |
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