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Superoxide, amine buffers and tetranitromethane: A novel free radical chain reaction

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1080/10715760000301081
AuthorSearch for: 1; Search for: 1
Affiliation
  1. National Research Council of Canada
FormatText, Article
Subjectamine; free radical; superoxide; tetranitromethane; aqueous solution; chemical reaction; chemical structure; oxidative stress; pH; reaction analysis; buffers; free Radicals; HEPES; morpholines; oxidation-reduction; superoxides; tetranitromethane
Abstract
The amine buffer Tris slowly reduces tetranitromethane (TNM) to the nitroform anion in a non-accelerating reaction. The amine buffers HEPES and MOPS also (slowly) react with TNM but the dialkylaminoalkyl radicals formed from these two buffers undergo further reactions resulting in a rapid, accelerating, free radical chain process whereby the amine is oxidized and TNM reduced. The chemical functionality in any reaction component, not necessarily the buffer, required for this radical chain mechanism is >N-CH<. In the presence of such groups, the quantification of superoxide by TNM is impossible.
Publication date
In
  • Free Radical Research 33, no. 5 (2000): 547–550.
LanguageEnglish
Peer reviewedYes
NPARC number21276779
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Record identifier22411902-b736-4ae1-a1c5-6c08bce26bef
Record created2015-10-13
Record modified2020-03-26
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