Structure of the LPS O-chain from Fusobacterium nucleatum strain 12230

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1016/j.carres.2017.06.007
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Name affiliation
  1. National Research Council of Canada. Human Health Therapeutics
FormatText, Article
Journal titleCarbohydrate Research
ISSN0008-6215
1873-426X
Volume448
Pages115–117
SubjectFusobacterium nucleatum; lipopolysaccharide; NMR spectroscopy; polysaccharide structure
Abstract
Fusobacterium nucleatum is an anaerobic bacterium found in the human mouth where it causes periodontitis. It was also found in colorectal cancer tissues and is linked with pregnancy complications, including pre-term and still births. Cell surface structures of the bacterium could be implicated in pathogenesis. Here we report the following structure of the lipopolysaccharide O-chain of F. nucleatum strain 12230: -6-α-d-Glc-4-β-d-GlcNHBu3NHBuA-3-β-d-QuiNAc4NABu- where ABu and HBu indicate (R)-3-aminobutanoyl and (R)-3-hydroxybutanoyl, respectively; all monosaccharides are in the pyranose form.
Publication date
PublisherElsevier
LanguageEnglish
Peer reviewedYes
NPARC number23002270
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Record identifier228149ac-c50c-4901-8086-6ebfb341f158
Record created2017-09-27
Record modified2020-03-16
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