| DOI | Resolve DOI: https://doi.org/10.1117/12.460783 |
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| Author | Search for: Attas, Michael1; Search for: Sowa, Michael G.1; Search for: Posthumus, Trevor B.1; Search for: Schattka, Bernhard J.1; Search for: Mantsch, Henry H.1; Search for: Zhang, Shuliang L. |
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| Editor | Search for: Mahadevan-Jansen, Anita; Search for: Mantsch, Henry H.1; Search for: Puppels, Gerwin J. |
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| Name affiliation | - National Research Council of Canada. NRC Institute for Biodiagnostics
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| Format | Text, Book chapter |
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| Proceedings title | Biomedical Vibrational Spectroscopy II |
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| Series title | Proceedings of SPIE; Volume 4614 |
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| Conference | International Symposium on Biomedical Optics, January 19, 2002, San Jose, CA, USA |
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| Pages | 79–88 |
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| Subject | spectroscopic imaging; near infrared; skin hydration; principal components analysis; fiber optic spectrometer |
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| Abstract | Near-infrared spectroscopic methods have been developed to determine the degree of hydration of human skin in vivo. Reflectance spectroscopic imaging was used to investigate the distribution of skin moisture as a function of location. A human study in a clinical setting has generated quantitative data showing the effects of a drying agent and a moisturizer on delineated regions of the forearms of eight volunteers. Two digital imaging systems equipped with liquid-crystal tunable filters were used to collect stacks of monochromatic images at 10-nm intervals over the wavelength bands 650-1050 nm and 960-1700 nm. Images generated from measurements of water absorption-band areas at three different near-IR wavelengths (970, 1200, and 1450 nm) showed obvious differences in the apparent distribution of water in skin. Changes resulting from the skin treatments were much more evident in the 1200-nm and 1450-nm images than in the 970-nm ones. The variable sensitivity of the method at different wavelengths has been interpreted as being the result of different penetration depths of the infrared light used in the reflectance studies. Ex-vivo experiments with pigskin have provided evidence supporting the relationship between wavelength and penetration depth. Combining the hydration results from several near-IR water bands allows additional information on hydration depth to be obtained. |
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| Publication date | 2002-03-28 |
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| Publisher | SPIE |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 23000787 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction |
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| Record identifier | 28e4e59f-a5f8-4fc1-a78a-f4b0d40b283f |
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| Record created | 2016-09-26 |
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| Record modified | 2020-03-03 |
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