The cell motility modulator Slit2 is a potent inhibitor of platelet function

From National Research Council Canada

DOI	Resolve DOI: https://doi.org/10.1161/CIRCULATIONAHA.112.105452
Author	Search for: Patel, Sajedabanu; Search for: Huang, Yi-Wei; Search for: Reheman, Adili; Search for: Pluthero, Fred G.; Search for: Chaturvedi, Swasti; Search for: Mukovozov, Ilya M.; Search for: Tole, Soumitra; Search for: Liu, Guang-Ying; Search for: Li, Ling; Search for: Durocher, Yves¹; Search for: Ni, Heyu; Search for: Kahr, Walter H. A.; Search for: Robinson, Lisa A.
Affiliation	National Research Council of Canada. Human Health Therapeutics
Format	Text, Article
Subject	blood cells; blood platelets; thrombosis
Abstract	Background—Vascular injury and atherothrombosis involve vessel infiltration by inflammatory leukocytes, migration of medial vascular smooth muscle cells to the intimal layer, and ultimately acute thrombosis. A strategy to simultaneously target these pathological processes has yet to be identified. The secreted protein, Slit2, and its transmembrane receptor, Robo-1, repel neuronal migration in the developing central nervous system. More recently, it has been appreciated that Slit2 impairs chemotaxis of leukocytes and vascular smooth muscle cells toward diverse inflammatory attractants. The effects of Slit2 on platelet function and thrombus formation have never been explored.
Publication date	2012-08-03
In	Circulation 126 (3 August 2012): 1385–1395.
Language	English
Peer reviewed	Yes
NRC number	NRCC 53204
NPARC number	21268297
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Record identifier	2ea65dd3-828d-4158-b258-a90be168c360
Record created	2013-06-17
Record modified	2020-04-21

Date modified:: 2024-07-19