Investigations into the binding of jadomycin DS to human topoisomerase IIβ by WaterLOGSY NMR spectroscopy

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1039/c5ob01508a
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Name affiliation
  1. National Research Council of Canada. Aquatic and Crop Resource Development
FormatText, Article
Journal titleOrganic and Biomolecular Chemistry
ISSN1477-0520
Volume13
Issue41
Pages10324–10327
SubjectMetabolites; Nuclear magnetic resonance spectroscopy; Anti-fungal; Antibacterial properties; Anticancer targets; Direct bindings; Human topoisomerase; Molecular mechanism; Secondary metabolites; Bins
Abstract
The jadomycins are a family of secondary metabolites produced by S. venezuelae ISP5230. Specific jadomycins have been shown to possess a variety of anticancer, antifungal, and antibacterial properties, with different molecular mechanisms of action. Herein we demonstrate qualitative and quantitative direct binding between the validated anticancer target human topoisomerase IIβ and jadomycin DS using WaterLOGSY NMR spectroscopy. Additionally, we report for the first time, that jadomycin DS also binds a variety of other proteins, likely in a non-specific manner. Such interactions may rationalize the potential polypharmacology of jadomycin DS.
Publication date
PublisherRoyal Society of Chemistry
LanguageEnglish
Peer reviewedYes
NPARC number21276974
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Record created2015-11-10
Record modified2020-04-22
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