| DOI | Resolve DOI: https://doi.org/10.1039/c5ob01508a |
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| Author | Search for: Martinez-Farina, Camilo F.; Search for: McCormick, Nicole; Search for: Robertson, Andrew W.; Search for: Clement, Helen; Search for: Jee, Alison; Search for: Ampaw, Anna; Search for: Chan, Nei-Li; Search for: Syvitski, Ray T.1; Search for: Jakeman, David L. |
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| Affiliation | - National Research Council of Canada. Aquatic and Crop Resource Development
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| Format | Text, Article |
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| Subject | Metabolites; Nuclear magnetic resonance spectroscopy; Anti-fungal; Antibacterial properties; Anticancer targets; Direct bindings; Human topoisomerase; Molecular mechanism; Secondary metabolites; Bins |
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| Abstract | The jadomycins are a family of secondary metabolites produced by S. venezuelae ISP5230. Specific jadomycins have been shown to possess a variety of anticancer, antifungal, and antibacterial properties, with different molecular mechanisms of action. Herein we demonstrate qualitative and quantitative direct binding between the validated anticancer target human topoisomerase IIβ and jadomycin DS using WaterLOGSY NMR spectroscopy. Additionally, we report for the first time, that jadomycin DS also binds a variety of other proteins, likely in a non-specific manner. Such interactions may rationalize the potential polypharmacology of jadomycin DS. |
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| Publication date | 2015-08-15 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 21276974 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 3505684d-154c-4e79-88df-7038847deb37 |
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| Record created | 2015-11-10 |
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| Record modified | 2020-04-22 |
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