| Download | - View accepted manuscript: Silicon photonic wire biosensor array for multiplexed, real-time and label-free molecular detection (PDF, 679 KiB)
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| DOI | Resolve DOI: https://doi.org/10.1364/OL.34.003598 |
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| Author | Search for: Densmore, A.1; Search for: Vachon, M.1; Search for: Xu, D.-X.1; Search for: Janz, S.1; Search for: Ma, R.1; Search for: Li, Y.-H.2; Search for: Lopinski, G.2; Search for: Delâge, A.1; Search for: Lapointe, J.1; Search for: Luebbert, C. C.3; Search for: Liu, Q. Y.3; Search for: Cheben, P.1ORCID identifier: https://orcid.org/0000-0003-4232-9130; Search for: Schmid, J. H.1 |
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| Affiliation | - National Research Council of Canada. NRC Institute for Microstructural Sciences
- National Research Council of Canada. NRC Steacie Institute for Molecular Sciences
- National Research Council of Canada. NRC Institute for Biological Sciences
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| Format | Text, Article |
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| Subject | silicon; photonic wire; waveguide; biosensor; array chip; monitoring; binding reactions |
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| Abstract | We demonstrate a silicon photonic wire waveguide biosensor array chip for the simultaneous monitoring of different molecular binding reactions. The chip is compatible with automated commercial spotting tools and contains a monolithically integrated microfluidic channel for sample delivery. Each array sensor element is a 1.8-mm-long spiral waveguide folded within a 130 µm diameter spot and is incorporated in a balanced Mach–Zehnder interferometer with a near temperature independent response. The sensors are arranged in a 400 µm spacing grid pattern and are addressed through cascaded 1x2 optical power splitters using light from a single input fiber. We demonstrate the real-time monitoring of antibody–antigen reactions using complementary and mismatched immunoglobulin G receptor–analyte pairs and bovine serum albumin. The measured level of detection for each sensor element corresponds to a surface coverage of less than 0.3 pg/mm². |
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| Publication date | 2009-12-01 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 15329309 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 37a446c4-3af0-4f01-98ab-bb6b3c28bdb1 |
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| Record created | 2010-05-21 |
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| Record modified | 2020-04-16 |
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