| DOI | Resolve DOI: https://doi.org/10.1117/12.166733 |
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| Author | Search for: Choo, Lin-P'ing1; Search for: Jackson, Michael1; Search for: Halliday, William C.; Search for: Mantsch, Henry H.1 |
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| Affiliation | - National Research Council of Canada. NRC Institute for Biodiagnostics
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| Format | Text, Book Chapter |
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| Conference | 9th International Conference on Fourier Transform Spectroscopy, August 23, 1993, Calgary, Alberta, Canada |
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| Abstract | The abnormal abundance of (beta) -amyloid plaques and neurofibrillary tangles are the hallmark of Alzheimer's disease (AD). Human central nervous system (CNS) grey matter was probed for characteristics arising from these pathological features. In AD but not normal grey matter, an IR band at 1615 cm-1 is seen, characteristic of a protein in an aggregated state. We speculate that this band arises from (beta) A4-amyloid protein. AD, and 18q- grey matter spectra show increased intensity of phosphate bands in accordance with known hyperphosphorylation of proteins found in neurofibrillary tangles. These spectral features may be useful in the diagnosis of AD. |
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| Publication date | 1994-01-31 |
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| Publisher | SPIE |
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| In | |
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| Series | |
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| Language | English |
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| Peer reviewed | Yes |
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| NRC number | NRC-IBD-3 |
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| NPARC number | 9743009 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 37d7789b-3268-4d9a-a02e-dd1cf52690cd |
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| Record created | 2009-07-17 |
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| Record modified | 2020-03-03 |
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