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Hypoglycemic effect of Aemotoxylon campechanum on streptozotocin (STZ)-induced diabetic rats

From National Research Council Canada

Linkhttp://ci.nii.ac.jp/naid/110001846587
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FormatText, Article
Subjecthypoglycemic effect; streptozotocin; guainane-type sesquiterpene; coumarin; Aematoxylon campechanum
Abstract
Hypoglycemic activity of Aemotoxylon campechanum was examined in STZ-induced diabetic rats. The water extract of A. campechanum lowered fasting blood glucose level of STZ-induced diabetic rats significantly and dosedependently. The water extract further divided into MeOH and H_2O-soluble fractions. The MeOH-soluble fraction showed the strongest hypoglycemic effect, which lowered fasting blood glucose level by 37% at a dose of 100 mg/kg (i. p.). The water extract and the MeOH-soluble fraction were found to be more effective in lowering the blood glucose level of diabetic rats than the mixtures of tolbutamide (200 mg/kg) and buformin (1 mg/kg) used as positive control, which lowered blood glucose level by 35.1%. The active fraction led to isolation of five guainane-type sesquiterpenes and a coumarin derivative.
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  • Journal of Traditional Medicines 20, no. 2 (20 April 2003): 57–61.
LanguageEnglish
Peer reviewedYes
NRC publication
This is a non-NRC publication

"Non-NRC publications" are publications authored by NRC employees prior to their employment by NRC.

NPARC number21274351
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Record identifier3b8958d8-2ec8-419b-9816-0cced9fbadf7
Record created2015-03-10
Record modified2023-11-01
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