Infrared spectroscopic characterisation of multiple sclerosis plaques in the human central nervous system

DOI	Resolve DOI: https://doi.org/10.1016/0925-4439(93)90078-F
Author	Search for: Choo, Lin-P'ing¹; Search for: Jackson, Michael¹; Search for: Halliday, William C.; Search for: Mantsch, Henry H.¹
Affiliation	National Research Council of Canada. NRC Institute for Biodiagnostics
Format	Text, Article
Subject	Infrared spectroscopy; Multiple sclerosis; Multiple sclerosis plaque; Central nervous system; (Human)
Abstract	Fourier transform infrared spectroscopy has been used for the characterisation of white matter, grey matter and multiple sclerosis plaques from human central nervous system tissue. We demonstrate significant differences in the infrared spectra of the three types of tissue, which show that an infrared spectroscopic discrimination of multiple sclerosis plaques from healthy brain tissue is possible in principle. The spectral changes reveal pronounced lipid loss in plaques, consistent with the demyelinating nature of the disease. The chronic plaques studied here can also be distinguished from other non-myelinated areas of the brain, based on difference in water content.
Publication date	1993-10
In	Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1182, no. 3: 333–337.
Language	English
Peer reviewed	Yes
NRC number	4 34726
NPARC number	9742413
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Record identifier	48e0f789-8b33-4715-9591-5aa654bc02fe
Record created	2009-07-17
Record modified	2020-04-24