| DOI | Resolve DOI: https://doi.org/10.1126/science.1235381 |
|---|
| Author | Search for: Amunts, K.; Search for: Lepage, C.; Search for: Borgeat, L.1; Search for: Mohlberg, H.; Search for: Dickscheid, T.; Search for: Rousseau, M.-É.; Search for: Bludau, S.; Search for: Bazin, P.-L.; Search for: Lewis, L.B.; Search for: Oros-Peusquens, A.-M.; Search for: Shah, N.J.; Search for: Lippert, T.; Search for: Zilles, K.; Search for: Evans, A.C. |
|---|
| Affiliation | - National Research Council of Canada
|
|---|
| Format | Text, Article |
|---|
| Subject | brain; histology; hominid; hypothesis testing; numerical model; brain; brain mapping; brain region; human tissue; model; neuroanatomy; primary motor cortex; simulation; tissue section; ultrahigh resolution three dimensional model; Aged; Brain; Brain Mapping; Cerebral Cortex; Female; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Microtomy |
|---|
| Abstract | Reference brains are indispensable tools in human brain mapping, enabling integration of multimodal data into an anatomically realistic standard space. Available reference brains, however, are restricted to the macroscopic scale and do not provide information on the functionally important microscopic dimension. We created an ultrahigh-resolution three-dimensional (3D) model of a human brain at nearly cellular resolution of 20 micrometers, based on the reconstruction of 7404 histological sections. "BigBrain" is a free, publicly available tool that provides considerable neuroanatomical insight into the human brain, thereby allowing the extraction of microscopic data for modeling and simulation. BigBrain enables testing of hypotheses on optimal path lengths between interconnected cortical regions or on spatial organization of genetic patterning, redefining the traditional neuroanatomy maps such as those of Brodmann and von Economo. |
|---|
| Publication date | 2013 |
|---|
| In | |
|---|
| Language | English |
|---|
| Peer reviewed | Yes |
|---|
| NPARC number | 21270714 |
|---|
| Export citation | Export as RIS |
|---|
| Report a correction | Report a correction (opens in a new tab) |
|---|
| Record identifier | 4a8c62e3-6d03-4044-b981-639e0d2a527b |
|---|
| Record created | 2014-02-17 |
|---|
| Record modified | 2020-04-22 |
|---|
