| DOI | Resolve DOI: https://doi.org/10.1016/j.exppara.2010.02.009 |
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| Author | Search for: Min-Oo, Gundula; Search for: Ayi, Kodjo; Search for: Bongfen, Silayuv E.; Search for: Tam, Mifong; Search for: Radovanovic, Irena; Search for: Gauthier, Susan; Search for: Santiago, Helton; Search for: Rothfuchs, Antonio Gigliotti; Search for: Roffê, Ester; Search for: Sher, Alan; Search for: Mullick, Alaka1; Search for: Fortin, Anny; Search for: Stevenson, Mary M.; Search for: Kain, Kevin C.; Search for: Gros, Philippe |
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| Affiliation | - National Research Council of Canada. NRC Biotechnology Research Institute
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| Format | Text, Article |
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| Subject | activity; anti-parasitic; apicomplexa; biotechnology; blood; brain; candida; candida albicans; cell; central nervous system; cysteamine; cysteine; deficiency; endocytosis; epithelial cells; gene; genetics; genome; immunology; in vitro; inflammation; interleukin-12; metabolism; methods; mice; microbiology; mouse model; mutation; pathology; pharmacokinetics; pharmacology; phospholipids; plasmodium; pressure; protease; protein; stress; synthesis; therapy; vitro |
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| Abstract | In mice, loss of pantetheinase activity causes susceptibility to infection with Plasmodium chabaudi AS. Treatment of mice with the pantetheinase metabolite cysteamine reduces blood-stage replication of P. chabaudi and significantly increases survival. Similarly, a short exposure of Plasmodium to cysteamine ex vivo is sufficient to suppress parasite infectivity in vivo. This effect of cysteamine is specific and not observed with a related thiol (dimercaptosuccinic acid) or with the pantethine precursor of cysteamine. Also, cysteamine does not protect against infection with the parasite Trypanosoma cruzi or the fungal pathogen Candida albicans, suggesting cysteamine acts directly against the parasite and does not modulate host inflammatory response. Cysteamine exposure also blocks replication of P. falciparum in vitro; moreover, these treated parasites show higher levels of intact hemoglobin. This study highlights the in vivo action of cysteamine against Plasmodium and provides further evidence for the involvement of pantetheinase in host response to this infection. -¬ 2010 Elsevier Inc |
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| Publication date | 2010 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NRC number | NRCC 52759 |
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| NPARC number | 16225331 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 4c8f59b8-8419-4563-98c6-e0f0f9723350 |
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| Record created | 2010-11-05 |
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| Record modified | 2020-04-17 |
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