Machine learning methods for analysis of metabolic data and metabolic pathway modeling

From National Research Council Canada

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DOIResolve DOI: https://doi.org/10.3390/metabo8010004
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  1. National Research Council of Canada. Digital Technologies
FormatText, Article
Journal titleMetabolites
ISSN2218-1989
2218-1989
Volume8
Issue1
Article number4
Pages# of pages: 16
Subjectsystem biology; metabolomics; metabolism modeling; machine learning; genomics
Abstract
Machine learning uses experimental data to optimize clustering or classification of samples or features, or to develop, augment or verify models that can be used to predict behavior or properties of systems. It is expected that machine learning will help provide actionable knowledge from a variety of big data including metabolomics data, as well as results of metabolism models. A variety of machine learning methods has been applied in bioinformatics and metabolism analyses including self-organizing maps, support vector machines, the kernel machine, Bayesian networks or fuzzy logic. To a lesser extent, machine learning has also been utilized to take advantage of the increasing availability of genomics and metabolomics data for the optimization of metabolic network models and their analysis. In this context, machine learning has aided the development of metabolic networks, the calculation of parameters for stoichiometric and kinetic models, as well as the analysis of major features in the model for the optimal application of bioreactors. Examples of this very interesting, albeit highly complex, application of machine learning for metabolism modeling will be the primary focus of this review presenting several different types of applications for model optimization, parameter determination or system analysis using models, as well as the utilization of several different types of machine learning technologies.
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PublisherMDPI
LanguageEnglish
Peer reviewedYes
NPARC number23002771
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Record identifier4ce26793-7a5e-4a26-81ca-f83ad14fe94d
Record created2018-02-05
Record modified2020-05-30
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