| Download | - View accepted manuscript: Characterization of a Dispiroketal Spirolide Subclass from Alexandrium ostenfeldii (PDF, 578 KiB)
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| DOI | Resolve DOI: https://doi.org/10.1021/np800795q |
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| Author | Search for: Roach, Joy S.1; Search for: LeBlanc, Patricia1; Search for: Lewis, Nancy I.1; Search for: Munday, Rex; Search for: Quilliam, Michael A.1; Search for: MacKinnon, Shawna L.1 |
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| Affiliation | - National Research Council of Canada. NRC Institute for Marine Biosciences
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| Format | Text, Article |
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| Subject | Marine toxin; spirolide h; spirolide i; unclassified drug; Alexandrium ostenfeldii; Dinophyceae |
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| Abstract | A new subclass of spirolide marine toxins, represented by spirolides H (1) and I (2), were isolated from the marine dinoflagellate Alexandrium ostenfeldii. Spirolides H and I are structurally distinct from other spirolides in that they contain a 5:6 dispiroketal ring system rather than the trispiroketal ring system characteristic of previously isolated spirolides. The structures were assigned using a combination of spectrometric and spectroscopic techniques. Previously isolated spirolides containing a cyclic imine moiety showed toxicity in the mouse bioassay. Spirolide H contains this cyclic imine moiety but does not show toxicity in the mouse assay, suggesting that the presence of the cyclic imine moiety is not the only structural requirement for toxicity. |
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| Publication date | 2009-07-24 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NRC number | NRCC 55468 |
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| NPARC number | 21268308 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 4ecc5f97-20a3-4c44-9102-a97c6b2fb80b |
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| Record created | 2013-06-19 |
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| Record modified | 2020-06-04 |
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