| DOI | Resolve DOI: https://doi.org/10.1016/j.bbrc.2010.09.081 |
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| Author | Search for: Chakravarthy, Balu1; Search for: Gaudet, Chantal1; Search for: Ménard, Michel1; Search for: Atkinson, Trevor1; Search for: Chiarini, Anna; Search for: Dal Prà, Illaria; Search for: Whitfield, James1 |
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| Affiliation | - National Research Council of Canada. NRC Institute for Biological Sciences
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| Format | Text, Article |
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| Subject | dentate gyrus; granule cell; hippocampus; primary cilium; p75NTR; TrkA receptor; Alzheimer disease transgenic mice |
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| Abstract | The densely ciliated granule cell layer of the adult murine hippocampal dentate gyrus is one of two sites of adult neurogenesis. The granule cells have already been proven to localize their SSTR3 (somatostatin receptor 3) receptors to their so-called primary cilia. Here we show for the first time that 70-90% of these cells in 7-18 months-old wild-type and 3xTg-AD (Alzheimer disease transgenic) mice also load p75ᴺᵀᴿ receptors into the structures containing SSTR3, i.e., their primary cilia. On the other hand, p75ᴺᵀᴿ's TrkA co-receptors were not localized to cilia but conventionally distributed throughout the cell surface. Significantly fewer cells (20-40%) in the hippocampal CA1 and CA3 regions and cerebral cortex have p75ᴺᵀᴿ containing cilia. While we don't know what the impact of the cilial localization of p75ᴺᵀᴿ on dentate gyral adult neurogenesis and memory encoding might be, the cilia-s amyloid β-activatable p75ᴺᵀᴿ receptors could be damaging or lethal to the hippocampal functioning of amyloid β-accumulating Alzheimer brain. |
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| Publication date | 2010-10-22 |
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| Publisher | Elsevier |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 17480639 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 4ef2cfcd-8445-4a42-b2b9-e54ee2135a00 |
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| Record created | 2011-03-30 |
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| Record modified | 2020-04-17 |
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