| Download | - View accepted manuscript: A comparison of methods using optical coherence tomography to detect demineralized regions in teeth (PDF, 1.7 MiB)
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| DOI | Resolve DOI: https://doi.org/10.1002/jbio.201100014 |
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| Author | Search for: Sowa, Michael G.1; Search for: Popescu, Dan P.1; Search for: Friesen, Jeri R.1; Search for: Hewko, Mark D.1; Search for: Choo-Smith, Lin-P'ing1 |
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| Affiliation | - National Research Council of Canada. NRC Institute for Biodiagnostics
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| Format | Text, Article |
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| Subject | Enamel demineralization; diagnostic discrimination; incipient caries detection; optical coherence tomography; lognormal fit; support vector machine classification |
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| Abstract | Optical coherence tomography (OCT) is a three-dimensional optical imaging technique that can be used to identify areas of early caries formation in dental enamel. The OCT signal at 850 nm back-reflected from sound enamel is attenuated stronger than the signal back-reflected from demineralized regions. To quantify this observation, the OCT signal as a function of depth into the enamel (also known as the A-scan intensity), the histogram of the A-scan intensities and three summary parameters derived from the A-scan are defined and their diagnostic potential compared. A total of 754 OCT A-scans were analyzed. The three summary parameters derived from the A-scans, the OCT attenuation coefficient as well as the mean and standard deviation of the lognormal fit to the histogram of the A-scan ensemble show statistically significant differences (p < 0.01) when comparing parameters from sound enamel and caries. Furthermore, these parameters only show a modest correlation. Based on the area under the curve (AUC) of the receiver operating characteristics (ROC) plot, the OCT attenuation coefficient shows higher discriminatory capacity (AUC = 0.98) compared to the parameters derived from the lognormal fit to the histogram of the A-scan. However, direct analysis of the A-scans or the histogram of A-scan intensities using linear support vector machine classification shows diagnostic discrimination (AUC = 0.96) comparable to that achieved using the attenuation coefficient. These findings suggest that either direct analysis of the A-scan, its intensity histogram or the attenuation coefficient derived from the descending slope of the OCT A-scan have high capacity to discriminate between regions of caries and sound enamel. |
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| Publication date | 2011-07-25 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 19726592 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 4ff23780-c600-4a5c-8044-0050e0b6afa4 |
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| Record created | 2012-03-28 |
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| Record modified | 2020-04-21 |
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