Part 3. A Novel Stereocontrolled, In Situ, Solution- and Solid-Phase, Aza Michael Approach for High-Throughput Generation of Tetrahydroaminoquinoline-Derived Natural-Product-like Architectures

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DOI	Resolve DOI: https://doi.org/10.1021/cc060059n
Author	Search for: Prakesch, Michael; Search for: Srivastava, Stuti; Search for: Leek, Donald M.¹; Search for: Arya, Prabhat¹
Affiliation	National Research Council of Canada. NRC Steacie Institute for Molecular Sciences
Format	Text, Article
Abstract	With the goal of rapidly accessing tetrahydroquinoline-based natural-product-like polycyclic architectures, herein, we report an unprecedented, in situ, stereocontrolled Aza Michael approach in solution and on the solid phase. The mild reaction conditions required to reach the desired target are highly attractive for the use of this method in library generation. To our knowledge, this approach has not been used before, and it opens a novel route leading to a wide variety of tetrahydroquinoline-derived bridged tricyclic derivatives.
Publication date	2006-09-11
In	Journal of Combinatorial Chemistry 8, no. 5 (11 September 2006): 762–773.
NPARC number	12339184
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Record identifier	51f42bf7-9f74-4405-a778-36652c06c3f7
Record created	2009-09-11
Record modified	2020-04-22