| DOI | Resolve DOI: https://doi.org/10.1016/j.mri.2009.01.023 |
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| Author | Search for: Gruwel, Marco L. H.1; Search for: Yang, Yanmin1; Search for: de Gervai, Patricia1; Search for: Sun, Jiankang1; Search for: Kupriyanov, Valery V.1 |
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| Affiliation | - National Research Council of Canada. NRC Institute for Biodiagnostics
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| Format | Text, Article |
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| Subject | Drug delivery; Alginate beads; MR contrast agent; Myocardial repair |
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| Abstract | Alginate-based beads labeled with contrast agent and loaded with vascular growth hormones were used for site-specific chronic delivery of hormones at the site of myocardial damage in a porcine model. Position of the beads within the pericardium could be monitored by MRI for optimal hormone delivery due to the presence of contrast agent. The beads facilitate the slow release of cytochrome c, myoglobin and methemoglobin used as protein models of growth factors. This application allows for site-specific delivery of hormones while the incorporated contrast agent in the beads provides a tool for MRI tracking in chronic studies. |
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| Publication date | 2009-04-15 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 20171301 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 550e7e01-a4dd-45c2-a466-9509c2432867 |
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| Record created | 2012-06-22 |
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| Record modified | 2020-04-16 |
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