| Author | Search for: Jing, Bi1; Search for: Hewitt, Melissa1; Search for: Fang, Hung1 |
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| Affiliation | - National Research Council of Canada. NRC Institute for Biological Sciences
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| Format | Text, Abstract |
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| Conference | Annual Meeting of the Society for Glycobiology (SFG 2010), November 7-10, 2010, St. Petersburg, Florida, USA |
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| Abstract | Factors that regulate neurite outgrowth are important in determining the wiring of the central nervous system. Glycosylation is known to play a role in regulation of neurite outgrowth. However, the underlying mechanisms remain unclear. Here we describe that a UDP-Gal:β GlcNAc β- 1,3-galactosyltransferase (B3GalT2) is strongly expressed in neurons in the layers V and VI of the cerebral cortex and in the hippocampus during postnatal development of the mouse brain. We also show that cortical layer V pyramidal neurons of B3GalT2 gene knockout mice exhibit reduced apical dendrite length, reduced spine numbers, and aberrant apical dendrite direction. Together, our results demonstrate for the first time that B3GalT2 is an important regulator of neuritogenesis. |
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| Publication date | 2010-11 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 17482878 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 56b91737-d9ce-4e58-ae55-c64c259e101a |
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| Record created | 2011-03-30 |
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| Record modified | 2020-09-24 |
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