| DOI | Resolve DOI: https://doi.org/10.1002/(SICI)1520-6343(1996)2:1<39::AID-BSPY4>3.0.CO;2-N |
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| Author | Search for: Liu, Kan-Zhi1; Search for: Mantsch, Henry H.1; Search for: Ramjiawan, Bram1; Search for: Pierce, Grant N. |
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| Affiliation | - National Research Council of Canada. NRC Institute for Biodiagnostics
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| Format | Text, Article |
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| Abstract | Infrared spectroscopy was applied to the investigation of normal and oxidatively modified hepatic nuclei. The hepatic nuclei were oxidized by two different free-radical-generating systems. Infrared spectra of oxidized nuclei were remarkably different from those of normal nuclei; the major alteration found in the spectra of oxidized nuclei was the emergence of a new population of nucleic acids with a hydrogen-bonding pattern different from that of the normal phosphodiester groups, and a redistribution of the hydrogen bonding of the protein amide groups of the histones, indicative of protein-structural rearrangements. The spectral changes in the phosphate bands of the nucleic acid resemble those previously observed in different types of malignant tissue, and suggest that there could be a link between nuclei oxidation and carcinogenesis which may involve a free-radical-mediated process. |
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| Publication date | 1996 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NRC number | 408 |
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| NPARC number | 9148533 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 5dbc6512-0307-40b3-96fc-47c996fc7bc4 |
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| Record created | 2009-06-25 |
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| Record modified | 2020-03-20 |
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