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Ultra-high resolution for mass spectrometric analysis of complex and low-abundance mixtures - the emergence of FTICR-MS as an essential analytical tool

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1007/s00216-002-1287-x
AuthorSearch for: 1ORCID identifier: https://orcid.org/0000-0002-0665-7041; Search for: 1; Search for: 1
Affiliation
  1. National Research Council of Canada. NRC Institute for Marine Biosciences
FormatText, Article
Abstract
The development of applications of mass spectrometry to chemical analysis has followed several paths, such as invention of new techniques for ionization, for acquisition of additional information concerning the relationship between fragment ions in the spectrum (tandem mass spectrometry), and for on-line coupling of a mass spectrometer to separatory techniques for real-time mixture analysis. Other features of any analytical instrument, such as sensitivity and detection limits, spectral acquisition rate, m/z range, etc., have, in mass spectrometry, often been driven by the need to match the low sample levels and higher resolution which have resulted from the introduction of capillary-based chromatographic methods.
Publication date
PublisherSpringer
In
  • Analytical and Bioanalytical Chemistry 373, no. 6 (13 April 2002): 378–389.
LanguageEnglish
Peer reviewedYes
NRC numberNRCC 42346
NRC-INMS-1357
NPARC number8899648
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Record identifier6079ae6d-8e8c-4d5d-b2ca-4a73c0833a39
Record created2009-04-22
Record modified2024-07-05
Date modified: