Download | - View accepted manuscript: A solution- and solid-phase approach to tetrahydroquinoline-derived polycyclics having a 10-membered ring (PDF, 772 KiB)
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DOI | Resolve DOI: https://doi.org/10.1021/cc049941o |
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Author | Search for: Khadem, Shahriar1; Search for: Joseph, Reni1; Search for: Rastegar, Majid1; Search for: Leek, Donald M.1; Search for: Oudatchin, Kostantin A.1; Search for: Arya, Prabhat1 |
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Affiliation | - National Research Council of Canada. NRC Steacie Institute for Molecular Sciences
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Format | Text, Article |
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ISSN | 1520-4766 |
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Abstract | With the goal of library generation using a polycyclic derivative 5 having an enamide functional group, a simple and practical, enantioselective synthesis of tetrahydroquinoline derivative 2 was achieved. The phenolic hydroxyl group in compound 2 was utilized as an anchoring site for solid-phase synthesis. The ring closing metathesis approach yielded the desired polycyclic product 5 on solid phase in five steps (overall 40% yield). Compound 5 is a novel scaffold for the library generation of natural product-like polycyclics having a functionalized medium ring for obtaining a new class of small molecules to be utilized as chemical probes. |
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Publication date | 2004-07-23 |
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In | |
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Language | English |
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Identifier | 18517171 |
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NPARC number | 12340957 |
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Export citation | Export as RIS |
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Report a correction | Report a correction (opens in a new tab) |
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Record identifier | 622ffa77-1e35-49ad-ae93-9b845cc2d3fe |
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Record created | 2009-09-11 |
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Record modified | 2020-04-17 |
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