Antiproliferative activity of Vietnamese medicinal plants

From National Research Council Canada

DOI	Resolve DOI: https://doi.org/10.1248/bpb.25.753
Author	Search for: Ueda, Jun-ya; Search for: Tezuka, Yasuhiro; Search for: Banskota, Arjun Hari; Search for: Tran, Quan Le; Search for: Tran, Qui Kim; Search for: Harimaya, Yuko; Search for: Saiki, Ikuo; Search for: Kadota, Shigetoshi
Format	Text, Article
Subject	antiproliferative activity; Streptocaulon juventas; Vietnamese plant; apoptosis; human HT-1080 fibrosarcoma; metastasis
Abstract	Methanol, methanol–water (1 : 1) and water extracts were prepared from seventy-seven Vietnamese medicinal plants and tested for their antiproliferative activities against human HT-1080 fibrosarcoma cells. Among them, fifteen extracts including seven methanol extracts of Caesalpinia sappan, Catharanthus roseus, Coscinium fenestratum, Eurycoma longifolia, Hydnophytum formicarum and Streptocaulon juventas (collected at two areas), six methanol–water (1 : 1) extracts of Cae. sappan, Cat. roseus, Co. fenestratum, H. formicarum and S. juventas (at two areas), and two water extracts of Cae. sappan and S. juventas exhibited antiproliferative activities in a concentration-dependent manner. Their antiproliferative activities against human cervix HeLa adenocarcinoma, human lung A549 adenocarcinoma, murine colon 26-L5 carcinoma, murine Lewis lung carcinoma (LLC) and murine B16-BL6 melanoma cells were then examined. Co. fenestratum showed selective activity against lung carcinoma and/or lung metastatic cell lines, A549, LLC and B16-BL6, while H. formicarum and S. juventas showed selective activity against human tumor cell lines, HeLa and A549. Characteristic morphological change and DNA fragmentation indicated the antiproliferative activity to be due to the induction of apoptosis.
Publication date	2002-06-01
Language	English
Peer reviewed	Yes
NRC publication	This is a non-NRC publication "Non-NRC publications" are publications authored by NRC employees prior to their employment by NRC.
NPARC number	21274778
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Record identifier	658020fc-7e8a-4d9b-a325-3002655f9494
Record created	2015-04-08
Record modified	2020-03-30

Date modified:: 2024-10-01