| DOI | Resolve DOI: https://doi.org/10.1016/j.peptides.2009.05.026 |
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| Author | Search for: Yang, Jun1; Search for: Yuan, Huifeng; Search for: Liu, Wenyan; Search for: Song, Chaoyou; Search for: Xu, Hongtao; Search for: Wang, Gen1; Search for: Song, Cai; Search for: Ni, Na; Search for: Yang, Daiwei; Search for: Lin, Baocheng |
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| Affiliation | - National Research Council of Canada. NRC Institute for Nutrisciences and Health
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| Format | Text, Article |
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| Subject | arginine vasopressin; pain modulation; hypothalamic paraventricular nucleus; nucleus raphe magnus |
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| Abstract | Hypothalamic paraventricular nucleus (PVN) is one of the main sources of arginine vasopressin (AVP) synthesis and secretion. AVP is the most important bioactive substance in PVN regulating pain process. Our pervious study has pointed that pain stimulation induced AVP increase in the nucleus raphe magnus (NRM), which plays a role in pain modulation. The present study was designed to investigate the source of AVP in the rat NRM during pain process using the methods of nucleus push–pull perfusion and radioimmunoassay. The results showed that pain stimulation increased the AVP concentration in the NRM perfusion liquid, PVN cauterization inhibited the role that pain stimulation induced the increase of AVP concentration in the NRM perfusion liquid, and PVN microinjection of l-glutamate sodium, which excited the PVN neurons, could increase the AVP concentration in the NRM perfusion liquid. The data suggested that AVP in the PVN might be transferred to the NRM to participate in pain modulation. |
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| Publication date | 2009-06-09 |
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| Publisher | Elsevier |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 23004518 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 67e179a3-124e-4716-8cc1-137c4f913886 |
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| Record created | 2018-11-14 |
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| Record modified | 2020-04-16 |
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