National Research Council of Canada. Information and Communication Technologies
One-pot syntheses of fluorescent o-aminobenzoates, o-aminopyridine carboxylates, and a 2′-amino-[1,1′-biphenyl]-2-carboxylic acid are described. Carbodiimides are used as the source of the 2-amino function which inserts onto an aromatic ring using S<inf>N</inf>Ar reaction conditions. This method proceeds regiospecifically with a range of 2-fluoroaromatic acids or esters bearing further aryl fluorine, trifluoromethyl, and cyano substituents.
Organic Letters17, no. 11 (20 May 2015): 2744–2747.