| Download | - View final version: Nanomedicine to overcome antimicrobial resistance: challenges and prospects (PDF, 2.2 MiB)
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| DOI | Resolve DOI: https://doi.org/10.2217/nnm-2023-0022 |
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| Author | Search for: Zou, Wei1ORCID identifier: https://orcid.org/0000-0002-8723-3311; Search for: McAdorey, Alyssa1; Search for: Yan, Hongbin; Search for: Chen, Wangxue1ORCID identifier: https://orcid.org/0000-0003-0958-7728 |
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| Affiliation | - National Research Council Canada. Human Health Therapeutics
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| Funder | Search for: Natural Sciences and Engineering Research Council of Canada; Search for: National Research Council Canada |
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| Format | Text, Article |
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| Subject | antimicrobial resistance; biological barriers; carbohydrates; immunological barrier; liposome; nanomedicine; targeted delivery |
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| Abstract | Translation of antibacterial nanoparticles into nanomedicine requires a deep understanding of the dynamic nature of nanoparticles and the ways they overcome immunological and biological barriers. Nanomedicines need prolonged serum stability by proper stealth coating or forming beneficial protein corona, to avoid rapid clearance by the mononuclear phagocytic system. A preferred nanoparticle formulation may include nonimmunogenic carbohydrates, which act both as a stealth coating and ligands of specific endothelium receptors to facilitate nanomedicines crossing the vascular barrier. This may lead to more rapid delivery and accumulation of nanomedicine at the infection site and provide broader and faster clinical responses than targeting specific bacterial surface receptors. Ideally, antibacterial nanomedicines should be able to penetrate biofilms through fusion and/or diffusion for targeted delivery. |
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| Publication date | 2023-05-12 |
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| Publisher | Taylor & Francis |
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| Licence | - Crown Copyright protection and licensed for use under the Open Government License unless otherwise indicated
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 6e046df5-fe23-49fd-896a-2fb16bb1bd6d |
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| Record created | 2024-10-18 |
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| Record modified | 2025-11-03 |
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