| Download | - View final version: Effects of micro/nanoplastics combined with three anthropogenic chemicals on larval zebrafish (Danio rerio): study of toxicity, behaviour and assessment of uptake (PDF, 3.7 MiB)
- View supplementary information: Effects of micro/nanoplastics combined with three anthropogenic chemicals on larval zebrafish (Danio rerio): study of toxicity, behaviour and assessment of uptake (DOCX, 3.4 MiB)
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| DOI | Resolve DOI: https://doi.org/10.1016/j.impact.2026.100623 |
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| Author | Search for: Hermabessiere, Ludovic1ORCID identifier: https://orcid.org/0000-0002-6775-2480; Search for: Levesque, Bailey1; Search for: Chilvers, Violet1; Search for: Tom, Justin1; Search for: Hui, Joseph P.M.1ORCID identifier: https://orcid.org/0009-0002-3241-012X; Search for: Vogt, Anja1; Search for: Ellis, Lee D.1 |
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| Affiliation | - National Research Council Canada. Aquatic and Crop Resource Development
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| Funder | Search for: National Research Council Canada |
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| Format | Text, Article |
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| Subject | fluoxetine; tetrabromobisphenol a; triphenyl phosphate; phenotype; effect concentration |
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| Abstract | Micro and nanoplastics are ubiquitous and can lead to adverse biological effects in exposed organisms. Organisms can also be co-exposed to plastics along with synthetic chemicals. In this work, using the NRC Zebrafish Embryo Toxicity test, we evaluated the potential toxicity of different sized plastic particles, along with the effects of combining them with the known toxicants, triphenyl phosphate, tetrabromobisphenol A and fluoxetine. Following chemical/plastic exposure, morphological abnormalities and behaviour were recorded, along with the chemical uptake of the toxicants by the larvae. The PS sphere particles used (0.42, 2.25 and 8.87 μm) exhibited no significant effects on larvae at the environmental concentrations tested (0.05–50 μg/mL) including no changes in larval behavioural activities. However, the presence of the micro/nanoplastic particles did increase the overt toxicity of the chemicals by changing their EC₅₀. Additionally, for all three chemicals, some plastic sizes decreased larval behaviour during the baseline or first light-dark period. Plastic particles did not modify the chemical uptake by the larvae. This suggests that enhanced toxicity caused by the plastics is not linked to changes in chemical uptake, metabolism, or excretion as hypothesized. Additional studies are necessary to better understand the role of plastic particles in a multiple stressor environment. |
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| Date published | 2026-04-01 |
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| Publisher | Elsevier B.V. |
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| Copyright statement | - Crown Copyright © 2026 Published by Elsevier B.V.
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| Language | English |
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| Peer reviewed | Yes |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 7370ad12-0bae-44d6-ae7e-d5fa9fac3349 |
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| Record created | 2026-05-19 |
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| Record modified | 2026-05-25 |
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