| Download | - View accepted manuscript: Multimodal nonlinear optical imaging of atherosclerotic plaque development in myocardial infarction prone rabbits (PDF, 771 KiB)
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| DOI | Resolve DOI: https://doi.org/10.1117/1.3353960 |
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| Author | Search for: Ko, Alex C. T.1; Search for: Ridsdale, Andrew2; Search for: Smith, Michael S. D.1; Search for: Mostaço-Guidolin, Leila B.1; Search for: Hewko, Mark D.1; Search for: Pegoraro, Adrian F.2; Search for: Kohlenberg, Elicia K.1; Search for: Schattka, Bernie1; Search for: Shiomi, Masashi; Search for: Stolow, Albert2; Search for: Sowa, Michael G.1 |
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| Affiliation | - National Research Council of Canada. NRC Institute for Biodiagnostics
- National Research Council of Canada. NRC Steacie Institute for Molecular Sciences
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| Format | Text, Article |
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| Subject | atherosclerosis; nonlinear optical microscopy; photonic crystal fiber; coherent anti-Stokes Raman scattering; two-photon excited fluorescence; second harmonic generation |
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| Abstract | Label-free imaging of bulk arterial tissue is demonstrated using a multimodal nonlinear optical microscope based on a photonic crystal fiber and a single femtosecond oscillator operating at 800 nm. Colocalized imaging of extracellular elastin fibers, fibrillar collagen, and lipid-rich structures within aortic tissue obtained from atherosclerosis-prone myocardial infarction-prone Watanabe heritable hyperlipidemic (WHHLMI) rabbits is demonstrated through two-photon excited fluorescence, second harmonic generation, and coherent anti-Stokes Raman scattering, respectively. These images are shown to differentiate healthy arterial wall, early atherosclerotic lesions, and advanced plaques. Clear pathological changes are observed in the extracellular matrix of the arterial wall and correlated with progression of atherosclerotic disease as represented by the age of the WHHLMI rabbits. |
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| Publication date | 2010-03-12 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NRC number | NRCC 20501 |
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| NPARC number | 16488516 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 73ee8f53-88f4-44ed-a5cc-35e09b6947ac |
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| Record created | 2011-02-15 |
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| Record modified | 2020-04-17 |
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