| DOI | Resolve DOI: https://doi.org/10.1117/12.875379 |
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| Author | Search for: Immucci, A.N.; Search for: Chamson-Reig, A.; Search for: Yu, K.1; Search for: Wilkinson, D.; Search for: Li, C.; Search for: Stodilka, R.Z.; Search for: Carson, J.J.L. |
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| Affiliation | - National Research Council of Canada. NRC Steacie Institute for Molecular Sciences
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| Format | Text, Article |
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| Conference | Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XI, January 23-26, 2011, San Francisco, CA, USA |
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| Subject | Ambient lighting; Biomedical applications; CdSe/ZnS quantum dots; Continuous exposure; Emission wavelength; End points; Equivalent concentrations; Gamma radiation; Gamma radiation sources; Gate widths; Green laser; Image samples; Light collection; Nd: YAG; Optical components; Pulse durations; Quantum Dot; Quantum Dots; Real-time dosimetry; Time-Gated Imaging; Time-periods; Dosimetry; Gamma rays; Imaging techniques; Industrial applications; Lighting; Neodymium lasers; Optical properties; Optical systems; Photoluminescence; Portals; Pulsed lasers; Quantum optics; Radiation; Semiconductor quantum dots; Quantum dot lasers |
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| Abstract | Quantum dots have been used in a wide variety of biomedical applications. A key advantage of these particles is that their optical properties depend predictably on size, which enables tuning of the emission wavelength. Recently, it was found that CdSe/ZnS quantum dots lose their ability to photoluminescence after exposure to gamma radiation (J. Phys. Chem. C., 113: 2580-2585 (2009). A method for readout of the loss of quantum dot photoluminescence during exposure to radiation could enable a multitude of real-time dosimetry applications. Here, we report on a method to image photoluminescence from quantum dots from a distance and under ambient lighting conditions. The approach was to construct and test a time-gated imaging system that incorporated pulsed illumination. The system was constructed from a pulsed green laser (Nd:YAG, 20 pulses/s, 5 ns pulse duration, ∼5 mJ/pulse), a time-gated camera (LaVision Picostar, 2 ns gate width), and optical components to enable coaxial illumination and imaging. Using the system to image samples of equivalent concentration to the previous end-point work, quantum dot photoluminescence was measureable under ambient room lighting at a distance of 25 cm from the sample with a signal to background of 7.5:1. Continuous exposure of samples to pulsed laser produced no measureable loss of photoluminescence over a time period of one hour. With improvements to the light collection optics the range of the system is expected to increase to several metres, which will enable imaging of samples during exposure to a gamma radiation source. © 2011 Copyright Society of Photo-Optical Instrumentation Engineers (SPIE). |
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| Publication date | 2011 |
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| Publisher | SPIE |
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| In | |
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| Series | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 21271242 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 79643c6d-82ca-46bf-bd92-44cc86665be1 |
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| Record created | 2014-03-24 |
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| Record modified | 2020-04-21 |
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