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Self-assembled rosette nanotubes from tetra guanine-cytosine modules

From National Research Council Canada

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DOIResolve DOI: https://doi.org/10.1039/D4NA00567H
AuthorSearch for: 1, 2ORCID identifier: https://orcid.org/0000-0001-5151-9484; Search for: 3, 2; Search for: 3, 2; Search for: 3; Search for: 3, 2, 4ORCID identifier: https://orcid.org/0000-0001-7629-7080
Affiliation
  1. National Research Council of Canada. Human Health Therapeutics
  2. University of Alberta. Department of Chemistry
  3. National Research Council of Canada. Nanotechnology
  4. University Mohammed VI Polytechnic
FunderSearch for: National Research Council of Canada; Search for: University of Alberta
FormatText, Article
Abstract
Self-assembly of small molecules into supramolecular architectures is a sustainable alternative to new advanced material design. Herein, the design and synthesis of a self-assembling system containing four covalently linked hybrid guanine and cytosine (G∧C) units that were connected through bifunctional amines are reported. These tetra G∧C motifs were characterized and self-assembled in water and methanol to produce discrete nanostructures. Each module has 24 sites for intermolecular hydrogen bonding and it is proposed that in solution the four G∧C units per molecule align into a linear stack which in turn self-assembles into a hexameric super-helix held together by 72 intermolecular hydrogen bonds. Stacking of these nano-helices led to the formation of quad rosette nanotubes.
Publication date
PublisherRoyal Society of Chemistry
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In
  • Nanoscale Advances 7, no. 1 (27 November 2024): 281–287.
LanguageEnglish
Peer reviewedYes
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Record identifier7a7f2572-d30b-4043-8457-3b472c2ed5bd
Record created2025-02-19
Record modified2025-02-19
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