| DOI | Resolve DOI: https://doi.org/10.1039/c2sc00663d |
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| Author | Search for: Dupuis, Stephanie N.; Search for: Robertson, Andrew W.; Search for: Veinot, Thomas; Search for: Monro, Susan M. A.; Search for: Douglas, Susan E.1; Search for: Syvitski, Ray T.2; Search for: Goralski, Kerry B.; Search for: McFarland, Sherri A.; Search for: Jakeman, David L. |
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| Affiliation | - National Research Council of Canada. Human Health Therapeutics
- National Research Council of Canada. Aquatic and Crop Resource Development
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| Format | Text, Article |
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| Abstract | Growth of Streptomyces venezuelae ISP5230 with O-propargyl-L-serine led to the efficient production of an alkyne-containing jadomycin. The installed alkyne functionality provided a uniquely reactive handle within the natural product and was subsequently reacted with a series of azides to afford an eight-member library of jadomycin triazoles. The compounds were evaluated for their DNA cleavage, antibacterial and cytotoxic properties. |
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| Publication date | 2012-05-01 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NRC number | NRCC 54067 |
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| NPARC number | 21268176 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 7c8ec638-71b5-4e4b-ab9f-182f8b017c28 |
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| Record created | 2013-05-16 |
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| Record modified | 2020-04-21 |
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