Alkaloid Production in Catharanthus roseus cell cultures. VII. Effect of parameter changes and catabolism studies on cell line PRL No. 953

DOI	Resolve DOI: https://doi.org/10.1002/hlca.19810640615
Author	Search for: Kutney, James P.; Search for: Choi, Lewis S. L.; Search for: Kolodziejczyk, Pawel; Search for: Sleigh, Stephen K.; Search for: Stuart, Kenneth L.; Search for: Worth, Brian R.; Search for: Kurz, Wolfgang G. W.¹; Search for: Chatson, Kenneth B.¹; Search for: Constabel, Friedrich¹
Affiliation	National Research Council of Canada. Prairie Regional Laboratory
Format	Text, Article
Abstract	Catharanthus roseus cells suspended in production medium showed the presence of four Aspidosperma-type alkaloids, however, no vindoline. Cells grown in media with the pH adjusted to 7.0 produced 3.3 mg total alkaloids/g dry weight. At pH 5.0, 1.7 mg of alkaloid/g dry weight was produced. (S)-Adenosyl-methionine did not stimulate the production of vindoline. When added to cell suspensions for 21 days, vindoline and catharanthine were degraded to non-alkaloidal substances, not dimerized to bisindole alkaloids.
Publication date	1981-09-23
Publisher	Wiley
In	Helvetica Chimica Acta 64, no. 6 (23 September 1981): 1837–1842.
Language	English
Peer reviewed	Yes
Identifier	NRCC-18656
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Record identifier	80ceb56c-6832-4818-bab9-60446d0e3677
Record created	2023-11-15
Record modified	2023-11-15