Two novel cytotoxic benzofuran derivatives from Brazilian propolis

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1021/np000143z
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FormatText
TypeArticle
Journal titleJournal of Natural Products
ISSN0163-3864
1520-6025
Volume63
Issue9
Pages1277–1279; # of pages: 3
Abstract
Two novel benzofuran derivatives, propolis-benzofurans A (1) and B (2), were isolated from the MeOH extract of Brazilian propolis, together with two known isoprenylated compounds (E)-3-[2,3-dihydro-2-(1-methylethenyl)-7-prenyl-5-benzofuranyl]-2-propenoic acid and (E)-3-{4-hydroxy-3-[(E)-4-(2,3-dihydrocinnamoyloxy)-3-methyl-2-butenyl]-5-prenylphenyl}-2-propenoic acid. The structures of these compounds were elucidated on the basis of spectral analysis. Both the new compounds exhibited mild cytotoxicity toward highly liver-metastatic murine colon 26-L5 carcinoma and human HT-1080 fibrosarcoma cells.
Publication date
LanguageEnglish
Peer reviewedYes
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NPARC number21275293
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Record identifier84811e4b-1354-4b56-8e19-efe18e5c935b
Record created2015-06-02
Record modified2016-05-09
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