Two novel cytotoxic benzofuran derivatives from Brazilian propolis

DOI	Resolve DOI: https://doi.org/10.1021/np000143z
Author	Search for: Banskota, Arjun H.; Search for: Tezuka, Yasuhiro; Search for: Midorikawa, Kiyoshi; Search for: Matsushige, Katsumichi; Search for: Kadota, Shigetoshi
Format	Text, Article
Journal title	Journal of Natural Products
ISSN	0163-3864 1520-6025
Volume	63
Issue	9
Pages	1277–1279
Abstract	Two novel benzofuran derivatives, propolis-benzofurans A (1) and B (2), were isolated from the MeOH extract of Brazilian propolis, together with two known isoprenylated compounds (E)-3-[2,3-dihydro-2-(1-methylethenyl)-7-prenyl-5-benzofuranyl]-2-propenoic acid and (E)-3-{4-hydroxy-3-[(E)-4-(2,3-dihydrocinnamoyloxy)-3-methyl-2-butenyl]-5-prenylphenyl}-2-propenoic acid. The structures of these compounds were elucidated on the basis of spectral analysis. Both the new compounds exhibited mild cytotoxicity toward highly liver-metastatic murine colon 26-L5 carcinoma and human HT-1080 fibrosarcoma cells.
Publication date	2000-09-01
Language	English
Peer reviewed	Yes
NRC publication	This is a non-NRC publication "Non-NRC publications" are publications authored by NRC employees prior to their employment by NRC.
NPARC number	21275293
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Record identifier	84811e4b-1354-4b56-8e19-efe18e5c935b
Record created	2015-06-02
Record modified	2020-03-26