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Alkaloid production in Catharanthus roseus cell cultures. XI. biotransformation of 3′, 4′‐anhydrovinblastine to other bisindole alkaloids

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1002/hlca.19820650417
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Affiliation
  1. National Research Council of Canada. Prairie Regional Laboratory
FormatText, Article
Abstract
Biotransformation studies of 3′,4′-anhydrovinblastine (1) in Calharanthus roseus cell suspension cultures are reported. A detailed study of one cell line, coded at „916”︁, has revealed that 1 is transformed to the natural bisindole alkaloids leurosine (2) and Catharine (3) in approximately 25–30 and 9–16% yield, respectively. In 24–48 h, about 40% of 1 is utilized by the cells. Conditions for biotransformation of 1 have not been optimized so the above yields quoted are not final.
Publication date
PublisherWiley
In
  • Helvetica Chimica Acta 65, no. 4 (16 June 1982): 1271–1278.
LanguageEnglish
Peer reviewedYes
IdentifierNRCC-20086
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Record identifier887d3d0e-4031-41af-bc8e-9a980feeb02e
Record created2023-11-16
Record modified2023-11-16
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