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Enzymatic surface erosion of poly(trimethylene carbonate) films studied by atomic force microscopy

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DOIResolve DOI: https://doi.org/10.1021/bm050460q
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FormatText, Article
Abstract
In this article, the surface erosion of spin-coated poly(trimethylene carbonate) (PTMC) films by lipase solutions from Thermomyces lanuginosus was studied using atomic force microscopy (AFM). PTMC films (23−48 nm thick) were stable in water at 37 °C for 16 h, while after immersion in lipase solutions at 37 °C for 30 s and 1 min, the average thickness of the film decreased in time at a rate of 11.0 ± 3.7 nm/min. The initially smooth films became significantly rougher during the erosion process. When the immersion time of the films in the lipase solutions was limited to less than 5 s, degradation of the surface was minimal and individual lipase molecules adsorbed on PTMC films could be discerned. By microcontact printing of the PTMC surfaces using a patterned PDMS stamp and lipase solution for 30 s, a predefined micropattern consisting of parallel, 5-μm-wide lines lying 5-nm deep and separated at a distance of 2 μm was formed. Friction images showed differences in surface properties between the recessed and protruding lines in the pattern.
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PublisherAmerican Chemical Society
In
  • Biomacromolecules 6, no. 6: 3404–3409.
LanguageEnglish
Peer reviewedYes
NRC publication
This is a non-NRC publication

"Non-NRC publications" are publications authored by NRC employees prior to their employment by NRC.

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Record identifier8c8f8f8f-90e1-4e44-aa55-2659dc9c3e79
Record created2019-04-15
Record modified2020-05-30
Date modified: