| Download | - View final version: An enveloped virus-like particle vaccine expressing a stabilized prefusion form of the SARS-CoV-2 spike protein elicits highly potent immunity (PDF, 1.3 MiB)
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| DOI | Resolve DOI: https://doi.org/10.1016/j.vaccine.2021.07.034 |
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| Author | Search for: Fluckiger, Anne-CatherineORCID identifier: https://orcid.org/0000-0002-4139-0741; Search for: Ontsouka, Barthelemy; Search for: Bozic, Jasminka; Search for: Diress, Abebaw; Search for: Ahmed, Tanvir; Search for: Berthoud, Tamara; Search for: Tran, Anh1ORCID identifier: https://orcid.org/0000-0003-0644-6014; Search for: Duque, Diane1; Search for: Liao, Mingmin; Search for: McCluskie, Michael1; Search for: Diaz-Mitoma, Francisco; Search for: Anderson, David E.ORCID identifier: https://orcid.org/0000-0003-1350-9431; Search for: Soare, Catalina |
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| Affiliation | - National Research Council of Canada. Human Health Therapeutics
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| Funder | Search for: ISED |
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| Format | Text, Article |
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| Subject | SARS-COV-2; vaccine; virus-like-particles; immunogenicity; neutralizing antibodies |
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| Abstract | We evaluated enveloped virus-like particles (eVLPs) expressing various forms of the Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike protein and several adjuvants in an effort to identify a highly potent Coronavirus disease 2019 (COVID-19) vaccine candidate. eVLPs expressing a modified prefusion form of SARS-CoV-2 spike protein were selected as they induced high antibody binding titers and neutralizing activity after a single injection in mice. Formulation of SARS-CoV-2 S eVLPs with aluminum phosphate resulted in balanced induction of IgG2 and IgG1 isotypes and antibody binding and neutralization titers were undiminished for more than 3 months after a single immunization. A single dose of this candidate, named VBI-2902a, protected Syrian golden hamsters from challenge with SARS-CoV-2 and supports the on-going clinical evaluation of VBI-2902a as a highly potent vaccine against COVID-19. |
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| Publication date | 2021-07-16 |
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| Publisher | Elsevier |
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| Licence | |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| Identifier | S0264410X21009117 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 8d80f04e-c26e-4ce5-b693-2e491570db49 |
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| Record created | 2022-09-06 |
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| Record modified | 2022-09-06 |
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