| DOI | Resolve DOI: https://doi.org/10.1016/S0924-2031(01)00165-5 |
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| Author | Search for: McIntosh, Laura M.1; Search for: Jackson, Michael1; Search for: Mantsch, Henry H.1; Search for: Mansfield, James R.1; Search for: Crowson, A. Neil; Search for: Toole, John W. P. |
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| Affiliation | - National Research Council of Canada. NRC Institute for Biodiagnostics
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| Format | Text, Article |
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| Conference | Shedding New Light on Disease: Optical Diagnostics for the New Millennium, June 25-30, 2000, Winnipeg, Canada |
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| Subject | Skin cancer; Near-infrared spectroscopy |
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| Abstract | The clinical diagnosis of many dermatological conditions suffers from inadequacies and a histopathological analysis of skin biopsies remains the standard for confirmation of a diagnosis. We suggest that near-infrared (IR) spectroscopy may be a suitable non-invasive, objective tool for characterizing skin conditions. This paper will highlight our in vivo near-IR spectroscopic characterization of skin tumors presented for differential diagnosis of skin cancer. In vivo visible and near-IR spectra (400–2500 nm) were collected from actinic keratoses, basal cell carcinomata, benign nevi, dysplastic nevi, actinic lentigines and seborrheic keratoses by placing a fiber optic probe on the skin. Linear discriminant analysis (LDA) was used to determine whether spectra could be classified according to lesion type and resulted in accuracies of 70–98% in differentiating benign from pre-malignant or malignant lesions. Near-IR spectroscopy is a promising non-invasive technique for the screening of skin lesions. |
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| Publication date | 2002-02-28 |
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| In | |
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| Peer reviewed | Yes |
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| NRC number | 1880 |
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| NPARC number | 9148339 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 8ef2788c-1d6d-48e7-b858-b62756aa26cd |
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| Record created | 2009-06-25 |
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| Record modified | 2020-03-30 |
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