Association of Gap-43 (neuromodulin) with microtubule-associated protein MAP-2 in neuronal cells

DOI	Resolve DOI: https://doi.org/10.1016/j.bbrc.2008.04.119
Author	Search for: Chakravarthy, Balu¹; Search for: Rashid, Amal¹; Search for: Brown, Leslie¹; Search for: Tessier, Luc¹; Search for: Kelly, John¹; Search for: Ménard, Michel¹
Affiliation	National Research Council of Canada. NRC Institute for Biological Sciences
Format	Text, Article
Subject	Gap-43; MAP-2; protein–protein interaction
Abstract	Gap-43 (B-50, neuromodulin) is a presynaptic protein implicated in axonal growth, neuronal differentiation, plasticity, and regeneration. Its activities are regulated by its dynamic interactions with various neuronal proteins, including actin and brain spectrin. Recently we have shown that Gap-43 co-localizes with an axonal protein DPYSL-3 in primary cortical neurons. In the present study we provide evidence that Gap-43 co-localizes and potentially interacts with microtubule-associated protein MAP-2 in adult and fetal rat brain, as well as in primary neuronal cultures. Our studies suggest that this interaction may be developmentally regulated.
Publication date	2008-05-01
Publisher	Elsevier
In	Biochemical and Biophysical Research Communications 371, no. 4: 679–683.
Language	English
Peer reviewed	Yes
NRC number	CHAKRAVARTHY2008
NPARC number	9358348
Export citation	Export as RIS
Report a correction	Report a correction (opens in a new tab)
Record identifier	91814ebb-d7ee-44e3-87c6-5072fb2a4bca
Record created	2009-07-10
Record modified	2020-04-15