| Download | - View final version: 2′-Fluoro-c-di-GMP as an oral vaccine adjuvant (PDF, 865 KiB)
- View supplementary information: 2′-Fluoro-c-di-GMP as an oral vaccine adjuvant (PDF, 945 KiB)
|
|---|
| DOI | Resolve DOI: https://doi.org/10.1039/C9RA08310C |
|---|
| Author | Search for: Li, Jia; Search for: Lee, Rhonda Kuo1; Search for: Chen, Wangxue1; Search for: Yan, HongbinORCID identifier: https://orcid.org/0000-0002-9087-0493 |
|---|
| Affiliation | - National Research Council Canada. Human Health Therapeutics
|
|---|
| Format | Text, Article |
|---|
| Abstract | Bis-(3′–5′)-cyclic dimeric 2′-deoxy-2′-fluoroguanosine monophosphate (2′-F-c-di-GMP) was synthesized through the modified H-phosphonate chemistry. Oral immunization of C57BL/6 mice with Helicobacter pylori cell-free sonicate extract adjuvanted with 2′-F-c-di-GMP led to the production of antigen-specific antibodies in feces and sera, and lowered bacterial counts in the stomach upon post-vaccination infections in immunized mice. Similarly, oral vaccination of BALB/c mice with flagillin proteins from Clostridium difficile and Listeria monocytogenes adjuvanted with 2′-F-c-di-GMP led to production of antigen-specific antibodies both systemically and mucosally. The adjuvanticity of 2′-F-c-di-GMP is associated with the enhanced induction of interferon γ. These results demonstrated the excellent oral adjuvanticity of 2′-F-c-di-GMP. |
|---|
| Publication date | 2019-12-16 |
|---|
| Publisher | Royal Society of Chemistry |
|---|
| Licence | |
|---|
| In | |
|---|
| Language | English |
|---|
| Peer reviewed | Yes |
|---|
| Export citation | Export as RIS |
|---|
| Report a correction | Report a correction (opens in a new tab) |
|---|
| Record identifier | 94a66d90-ff56-4295-987b-7da2daaef0ac |
|---|
| Record created | 2020-11-06 |
|---|
| Record modified | 2020-11-09 |
|---|
