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Recent advances in mass spectrometry imaging for multiomics application in neurology

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1002/cne.24571
AuthorSearch for: 1; Search for: 1
Affiliation
  1. National Research Council of Canada. Human Health Therapeutics
FormatText, Article
Subjectmass spectrometry; mouse brain; proteomics; metabolomics; glycomics; lipidomics
Abstract
Mass spectrometry imaging (MSI) has emerged as a powerful tool for multiomics study in neurology. MSI combines the multichannel (m/z) measurement capability of mass spectrometers with a surface sampling process that allows for rapid probing and mapping of the characterized intact proteins, proteolytic digested peptides, released glycans, phospholipids, glycolipids, and small metabolites in brain tissues. The present review is focused on the application of MSI to the study of proteomics, glycomics, peptidomics, metabolomics, and lipidomics in mouse brain tissues.
Publication date
PublisherWiley
In
  • Journal of Comparative Neurology.
LanguageEnglish
Peer reviewedYes
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Record identifier9af5876e-67ad-4012-a7f3-de02af37fb54
Record created2019-04-26
Record modified2020-03-16
Date modified: